Vitamin B12

Introduction:
Vitamin B12 is one of the eight B vitamins and plays an important role in cell metabolism. It is a water-soluble vitamin (i.e. it dissolves in water and after the body utilises it,  the leftover amounts leave the body through urine). Vitamin B12 contains the mineral cobalt in its chemical structure,  thus it is known as cobalamin. Methylcobalamin is its active form and cyanocobalamin is the principal form used in supplements. It is an important vitamin that not only helps in DNA synthesis but also in protein and fatty acid metabolism.
It is not made by plants or animals but is synthesized in nature by microorganisms (bacteria). The primary source of vitamin B12 is animal-derived foods like meat and fish because animals eat food contaminated with bacteria or they produce B12 internally by their intestinal bacteria which is absent in humans. The main vegetarian source of B12 can be dairy. As our body cannot make its vitamin B12 we need to get it from our diet or supplements.

FUNCTIONS

1. Helps in production of Red Blood Cells and thus prevent anemia – Deficiency of vitamin B12 inhibits RBC production and causes them to grow bigger and oval. These leads to megaloblastic anemia as the irregular RBCs are unable to migrate from bone marrow and they are unable to circulate at their average speed.
2. Helps in development and proper function of brain and nerve cells, thus prevent neuron degeneration– Vitamin B12 deficiency leads to brain atrophy and loss of memory in elderly people. Studies have proven that vitamin b12 along with omega-3 fatty acid have delayed mental deterioration in early stages of dementia and helped reduce memory loss.
3. Aids depression symptoms and elevates mood– as it helps in production and metabolism of neurotransmitter serotonin which regulates mood.
4. Prevents congenial abnormalities– Vitamin B12 is passed to the foetus by the mother via the placenta. It is necessary for the normal development of the foetal brain. Its deficiency during the first trimester of pregnancy may lead to defects in the foetus and risks of abortion or preterm labour.
5. Support bone health and prevents osteoporosis– Its deficiency leads to decreased mineral bone density thus leading to osteoporosis and increased risk of fractures, especially in women.
6. Reduces the risk of age-related macular degeneration which causes vision loss, particularly affecting central vision.
7. Reduces levels of amino acid homocysteine and thus aids heart health– High levels of homocysteine in the blood cause fat deposition in blood vessels and thus increase the risk of cardiovascular diseases.
8. Boosts body energy levels
9. Aids to healthy skin, hair and nails

DEFICIENCY OF VITAMIN B12 – It happens either when body is not getting enough amount in diet or the body is not absorbing it from food. Vegetarians and vegans are at high risk for developing deficiency.
Causes–

1. Low dietary intake
2. Diseases- gastritis, Crohn’s disease
3. Gastrointestinal surgeries- like gastric bypass
4. Chronic alcoholic

Symptoms–

1. Feeling tired and fatigued
2. Sore mouth (mouth ulcers)
3. Weight loss
4. Loss of appetite
5. Yellowish skin
6. Vision problems
7. Depressed
8. Irritable
9. Lack of concentration, confused
10. Balancing problem (not a stable gait)
11. Numbness of limbs
12. Tingling sensation in hands and feet

Toxicity of Vitamin B12
No adverse effects are noticed with excess intake of vitamin B12 as the body keeps the required amount of vitamin and flushes the excess in urine. But rarely, megadoses can harm a certain population.
Does heating affect Vitamin B12?
Cooking does not destroy vitamin B12.  But repeated microwave heating can lead to its degradation. Therefore, one should avoid reheating food.

Disclaimer:
The above information is for awareness and education purposes only and cannot be used for diagnosis or treatment of any condition. Please consult with a physician for any concerns or questions